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The crystal structure of the human enzyme cocrystallized with glutamate showed that the -carboxylate of the -glutamyl moiety of the substrate is stabilized within the active site of the enzyme by forming hydrogen bonds with Arg-107, Ser 451, and Ser-452S (West et al., 2013b)

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Casanova MF, Sokhadze EM, Casanova EL, Opris I, Abujadi C, Marcolin MA, et al

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Treatment of cholinesterase poisoning from organophosphorus or carbamate insecticides