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) and singlet oxygen ( 1 O 2 ), which are toxic for the cells [18]

Consequently, these results indicate that CeO 2 MnO 2 accumulates rapidly at tumor locations and becomes Mn 2+ , which can be used as a T1 contrast agent to guide tumor treatment in vivo, while this rapid metabolism also enhances biosafety

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To compare the effect of Nrf2 knockout in mESC-derived thyroid with zebrafish nrf2a5 mutants, the selected gRNA targets the same genomic region chosen for zebrafish, the DNA binding and transactivation of the Nrf2 gene

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