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There are no large, definitive phase III efficacy trials across major indications

Healthcare providers are strongly encouraged to do all of the following: Complete a REMS-compliant education program offered by an accredited provider of continuing education (CE) or another education program that includes all the elements of the FDA Education Blueprint for Health Care Providers Involved in the Management or Support of Patients with Pain

Phytochemistry 72, 15311537

doi: 10.1038/s41467-024-46986-2

10 It is important to recognise that the use of serial sequential monotherapy is often disappointing
