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The body compensates by increasing glucose oxidation and, more problematically, by increasing amino acid catabolism, which means breaking down muscle protein for energy

The effect of L-carnitine in reducing PT time is due to its antioxidant properties in the liver, which protects liver cells from damage [37]

In addition, another in vitro study showed that CRP significantly attenuated the flow-mediated activation of Akt, which mostly controls endothelial cell survival pathways, and in human mononuclear cells, CRP resulted in the production of TNF-, IL-1, and matrix metalloproteinase-9 in a concentration-dependent manner that was significantly inhibited by function-blocking antibodies to TNF-alpha, IL-1beta, and FcgammaRIIA [143]

Exp Neurol 196(1):112119

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