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Then, BA are further converted to the major secondary BA metabolized by the gut microbes [8, 9]

Potential role of mRNAs and LncRNAs in chronic intermittent hypoxia exposure-aggravated atherosclerosis

But when the same receptor gets hit with the same signal nonstop, a chain of events unfolds: The cell marks the receptor with a chemical tag (phosphorylation) A protein called beta-arrestin grabs the tagged receptor and shuts down further signaling The cell pulls the receptor inside (internalization) Some receptors get recycled and put back on the surface

doi: 10.1016/j.ccell.2019.04.002

259 Moreover, the loss of the mitochondrial ABC transporter ATM1, which transports intermediates required for FeS cluster formation, exacerbates Cu-induced toxicity