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There are in excess of 2300 publications devoted to Botox alone

The final aspect regarding clinical trials in SCA3 is the inclusion of this disease in a group of disorders based on similar clinical presentation (spinocerebellar ataxia) and pathogenesis (triplet repeat expansions) [260]

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For instance, in the case of advanced/metastatic non-small cell lung cancer (NSCLC) with METex14, GEOMETRY mono-1, a multicenter, open-label, multicohort phase 2 trial, demonstrated that capmatinib was highly effective against tumors in patients with advanced or metastatic NSCLC at stages IIIB and IV, particularly those with METex14 or MET amplification, especially in settings without prior treatment [27]

Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype