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Description
Conformational change in the ligand-binding domain has been a basic requirement for the construction of FRET-based nanosensors, and also for translating metabolite binding into a change in FRET 26
However, CF, PCD, and NCFB are rarer with incidences ranging from 1 in 20,000 for PCD, between 50 and 1,000 in 100,000 for NCFB, and around 160,000 individuals with CF worldwide (Nigro et al., 2024
M.WilsonS
Being precise about these is the difference between reading the literature accurately and being misled by it
IO is dealt with a focused attention, exploring molecular mechanisms and emerging therapeutic strategies
