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however, elevated levels of intracellular heme can lead to cellular damage: oxidation of proteins, inhibition of proteases, and damage or lysis of membranes [12,13,14]

Curcumin suppresses cell viability in Cutaneous T-cell lymphoma cells via induction of apoptosis and inhibits S-phase kinase protein 2 while upregulating growth arrest and DNA damage-inducible protein 45 alpha, cyclin-dependent kinase inhibitor 1A, and cyclin-dependent kinase inhibitor 1B, which are key regulators of the cell cycle

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All animals survived to completion of the study

10.1046/j.1365-3040.1999.00509.x Plant