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Are they necessary

Acupuncture for muscle spasms has a strong evidence base for both neck spasms and low back muscle spasms
For instance, in PD, loss of dopaminergic neurons leads to decreased dopamine levels, and in AD, the excitotoxicity of glutamate exacerbates neuronal damage (67)
A self-immolative prodrug nanosystem capable of releasing a drug and a NIR reporter for in vivo imaging and therapy

Bergdahl, J., Anneroth, G