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While normal wound healing progresses through controlled inflammation, proliferation, and remodeling, chronic wounds disrupted by bacterial biofilms experience prolonged inflammation, impaired angiogenesis, and delayed tissue restoration

The translation of findings from rodent models to humans is also often limited by inherent differences in BA metabolism and gut microbiota (63, 147, 163), necessitating rigorous validation in human studies

(B) Relative Standard Deviation (RSD) values within replicates for each group evaluate quantification variability

Role of endothelium-derived nitric oxide in the modulation of canine myocardial mitochondrial respiration in vitro