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Significant reductions in the amount and collagen structure can weaken the flexibility of the dermal layer, causing wrinkles and xerosis (71)

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Introduction Neurofibromatosis type 1 (NF1) is a genetic multisystem disorder that predisposes to the onset of several tumor types and is characterized by a number of clinical manifestations encompassing caf au lait macules in the skin, iris hamartomas (Lisch nodules), cognitive deficits, axillary or groin freckles, bone deformities, optic gliomas and Schwann cell neoplasms called neurofibromas