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5 Therapeutic strategies A variety of treatments are available for the alleviation of sicca symptoms, including the use of saliva substitutes

Under physiological conditions, HMGB1/2 are primarily localized in the nucleus, where they bind to DNA and contribute to nucleosome structural integrity

doi: 10.1001/archpsyc.1985.01790340041006

Adv Sci 10:e2206798

Rosenberg T, Gal-Ben-Ari S, Dieterich DC, Kreutz MR, Ziv NE, Gundelfinger ED, et al
