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Vouldoukis I, Lacan D, Kamat C, Coste P, Calenda A, Mazier D, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al

Notably, the symptoms deteriorate over time, markedly reducing the quality of later life

However, when there is an excess amount of cytosolic DA outside of the synaptic vesicle in damaged neurons, i.e., after L-DOPA treatment, DA is easily metabolized via monoamine oxidase (MAO) or by auto-oxidation to cytotoxic ROS (Zucca et al., 2014)

LAAM GSH-CQDs exhibited minimal interaction with serum proteins, extended circulation time, excellent hemocompatibility, and minimal immunogenicity (Fig