copper toxicity from ghk-cu peptide Making Skin Worse: Complete Troubleshooting Guide Expression and Purification of Recombinant
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The version a double board-certified plastic surgeon writes

The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism
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Using nasal spray during severe congestion dramatically reduces absorption

Cellular turnover: The outcome that surprises patients most