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Our study investigates the biological mechanism of action of the CLB-platinum(IV) prodrugs, [Pt(1,10-phenanthroline)( S , S -DACH)(CLB)(OH)](NO 3 ) 2 ( Pt IV PCLB ), [Pt(5-methyl-1,10-phenanthroline)( S , S -DACH)(CLB)(OH)](NO 3 ) 2 ( Pt IV 5CLB ), and [Pt(5,6-dimethyl-1,10-phenanthroline)( S , S -DACH)(CLB)(OH)](NO 3 ) 2 ( Pt IV 56CLB ), as illustrated in Scheme 1

These effects were contributed to increase in energy metabolism, insulin signaling pathway and suppression of GSK3/ and ERK 1/2 activity

Brosseau J

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