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It is a tetrameric enzyme consisting of four identical tetrahedrally arranged subunits of 60 kDa, which contains a single ferriprotoporphyrin group per subunit and has a molecular mass of about 240 kDa

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Consistent with this result, HPL flavonoids with a typical flavonol C6C3C6 carbon framework exhibited stable free radical scavenging activity by interacting with free radicals to form stable adducts and then generating neutral molecules via retro-Diels-Alder degradation (Liu et al., 2014a)

This will then trigger the release of pre-stored pro-inflammatory mediators 9 such as histamine and proteases, and the secretion of newly synthesized mediators such as cytokines or eicosanoids 10