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In a mouse model of coronary artery ligation-induced I/R injury, pretreatment with Fer-1 reduced the intermediate production of hydroperoxy-arachidonoyl-phosphatidylethanolamine, and subsequently decreased the myocardial cell mortality (77)

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For example, TNF- and IL-1 can inhibit the abundance of growth hormone receptors, while IL-6 plays a role in promoting the expression of suppressor of cytokine signaling 3 (SOCS3), which has an enhancing effect on GH resistance (134)

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