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systematic reviews point out inconsistencies in methodologies and outcomes in current research, indicating a critical gap in our understanding of how gut health can be effectively targeted for therapeutic gain in ME/CFS patients

These systems can model neurovascularglial interactions, BBB dysfunction and the combined astrocytemicroglia effects on oligodendrocyte survival and myelination, thereby enabling concurrent assessment of neuronal health, myelin dynamics, immune activation and vascular integrity with high experimental accessibility

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This phenomenon is similar to most adaptations, like lifting weights micro-tearing the muscle to make it stronger