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J Am Soc Nephrol 26:876887 Addi T, Poitevin S, McKay N, El Mecherfi KE, Kheroua O, Jourde-Chiche N, de Macedo A, Gondouin B, Cerini C, Brunet P et al (2019) Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor/nuclear factor-kappa B signaling pathway in human endothelial cells
doi: 10.1073/pnas.93.25.14960

doi: 10.1016/s0025-7125(05)70568-x
Since natural glutathione production also decreases, there's little defense against the increase in oxidative stress
