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Blocking B7 in this patient would prevent the crucial CD28-mediated costimulatory signal, thereby suppressing rather than enhancing the anti-tumor immune response needed to treat his metastatic melanoma

doi: 10.1016/j.cellsig.2012.01.008 116

Future work could determine the -globin-specific roles for hypoxia or oxidative stress responses in cell types mentioned above

Clinical trials indicate that IVC does not adversely interfere with chemotherapy and pre-clinical studies indicate that it may in fact act synergistically in combination with different chemotherapeutic agents

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