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-hydroxybutyrate, the most abundant ketone body, is mainly synthesized in the liver from circulating fats during times of starvation, extended exercise, or when carbohydrate intake is limited [41]

J Biol Chem 2020;295(46):1546615481

In brain, tight coupling between substrate delivery, mitochondrial ATP production, and local removal of metabolic by-products is essential to sustain axonal signaling and prevent excitotoxic and oxidative injury (Sheng, 2017

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