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In kidney transplantation, ischemia time and donor factors dictate initial graft function
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The compound's compatibility with both cell-based and biochemical assays makes it an effective reference standard and benchmarking tool for evaluating new chemical entities targeting related pathways
Since the response is dose-sensitive and even biphasic, careful studies test a spread of concentrations across several orders of magnitude rather than betting on one number
doi: 10.1016/j.taap.2005.12.013
