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Carnitine researcher and expert Stefan Siebrecht, PHD recommends supplementing in the 2 gram per day range (see reference 3 above)

Through AR, androgens play significant roles in female bone metabolism with flutamide-treated intact female rats displaying decreased femur mass, calcium content, and bone resorption rate [291]

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Despite the slow and steady nature of this change in the baseline relative to human time scales, on geological time scales, this change is more rapid than any change documented over the last 300 million years, so organisms that have evolved tolerance to a certain range of conditions may encounter increasingly stressful, or even lethal, conditions in the coming decades