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Patients with peripheral atherosclerotic disease (multibed disease) should be treated as patients with very high or extreme cardiovascular risk, and the treatment goal should be reduction of LDL-C concentration by 50% from baseline and achievement of the target LDL-C concentration of 100 mg/dl (2.6 mmol/l) and/or elevated TG concentration (children 8 years of age (accumulating data support lowering of this age even to 6 years), and in children with homozygous FH 500 mg/dl (12.9 mmol/l)) [344]