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NRF2 and resistance to genotoxic and targeted therapy NRF2 activity has been associated with resistance to chemotherapy, radiation and immunotherapy [12, 48, 51,52,53,54]

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The combination arm was terminated early due to severe adverse events and deaths, while NAC alone showed no significant effect on lung function, though secondary endpoints (6MWD, QoL) improved modestly (139)

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