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Internationally, the situation regarding the legalization and decriminalization of medicinal cannabis varies markedly

found that although androgen deprivation therapy inhibited the expression of renal glutaminase (KGA) in the GLS1 subtype, the expression of glutaminase C (GAC) was upregulated in tumor cells, which is an androgen-independent GLS1 subtype with stronger enzymatic activity

Indian Pediatr

Reducing iron toxicity accumulation and mitochondrial dysfunction through CISD1 gene inhibition enhances the process of erastin-induced iron ptosis, which does not involve GPx4 [43]

Several promising compounds have failed in clinical trials due to a range of challenges, including inadequate disease models, late intervention timing, insufficient biomarker validation, and difficulty in distinguishing symptomatic from neuroprotective effects