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Increased levels of ROS are accompanied by activation of the antioxidant system, further enhancing drug resistance ( 3.6.5 Redox regulation DTP cells survive drug-induced oxidative stress by increasing the expression of enzymes such as glutathione peroxidase 4 (GPX4) and aldehyde dehydrogenase (ALDH), scavenging harmful substances generated by oxidative stress, and maintaining intracellular redox balance ( In summary, these differences provide different targets and ideas for therapeutic strategies against DTP cells and LSCs

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