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10.1016/j.biopsych.2012.01.014 [DOI] [PMC free article] [PubMed] [Google Scholar] 24.Wink LK, Adams R, Wang Z, Klaunig JE, Plawecki MH, Posey DJ, et al

More recent studies have demonstrated that, in addition to patients with germline mutations, those harboring de novo somatic mutations of BRCA1/2 and PALB2 also show benefit from PARP inhibitors, provided there is bi-allelic loss and established homologous repair deficiency in the tumors 89