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If time allows: Administer a conservative dose (e.g., based on ideal body weight) and then check the level two hours later

PrinsMLFujimaLSHovdaDA.Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury

Furthermore, FMO3 is regulated by farnesoid X receptor (FXR), a nuclear receptor activated by bile acid (Lefebvre et al., 2009), and injection of FXR ligands induced the expression of FMO3 and the production of TMAO in mice (Bennett et al., 2013)

It is worth noting that TMAO can also significantly increase the level of ROS in DCs through the mitochondrial dysfunction pathway

Additionally, although it does not cause systemic coagulopathy in mice, TMAO does downregulate thrombomodulin in human endothelial cells