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doi: 10.1111/and.13375 67 KalthurGAdigaSKUpadhyaDRaoSKumarP

Further, the interaction between CHAC1 and the ATF4-CHOP pathway elucidates a feedback loop where oxidative stress enhances ER stress, which in turn aggravates oxidative stress through CHAC1-mediated GSH depletion

DingYBuFChenTShiGYuanXFengZet al

All crystal structures have been deposited in the Protein Data Bank (PDB) with accession IDs: 8ENS (WD40 with wild-type S tail heptapeptide), 8ENW (WD40 with Thr1273Glu clientized S tail heptapeptide), 8ENX (WD40-Tyr33Ala with Thr1273Glu clientized S tail heptapeptide), 8ENY (WD40-Arg13Ala), 8ENZ (WD40-Lys15Ala), 8EO0 (WD40-Arg300Ala), and 8SZX (WD40-Lys17Ala)