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Rats co-treated with alamandine exhibited an insignificant increase in creatinine clearance compared to the DOX group ( p = 0.535)

Protein product purity of both systems is equivalent

In the CNS, melatonin is metabolized mainly by the enzyme indoleamine 2,3-dioxygenase (IDO), giving rise to the metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), which is subsequently transformed into N-acetyl-5-methoxykynuramine (AMK) [1,6]

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