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Arsenic trioxide (As 2 O 3 ) is a prooxidant chemotherapeutic compound combined with agents that deplete cellular GSH [116]

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Glutamate is the major excitatory neurotransmitter in the CNS and is involved in mechanisms of activity-dependent synaptic plasticity underlying learning and memory processes, such as long-term potentiation (LTP) and long-term depression (LTD) [108]

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Their interactions with key intracellular pathways, such as the nuclear factor Nrf2 pathway and MAPK signaling cascade, further amplify melanocyte vulnerability [88]