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It could be shown that glycolysis in ECs is mainly regulated by PFKFB3 ( in vivo in an EC-specific Pfkfb3 -deficient mouse model, demonstrating that the lack of Pfkfb3 results in decreased branch points and sprouts in a postnatal retina model (Gmez-Escudero et al., 2019), but also in reduced VE-cadherin expression resulting in destabilization of the cellular junctions (Gmez-Escudero et al., 2019)

Dtsch Arztebl Int 121 , 175181 (2024)

The final pipeline maintains the strongest ROC and precisionrecall behavior across the compared classifiers, showing that the advantage is not confined to a single operating point but persists across a broad range of decision thresholds

doi: 10.1038/s41598-024-53836-0, 47

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