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L-DOPA is incorporated into brain proteins of patients treated for Parkinsons disease, inducing toxicity in human neuroblastoma cells in vitro

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Human clinical trials remain limited and frequently include small cohorts, decreasing generalizability

These findings shed light on how exposome could affect DNA methylation of drug-metabolizing enzymes and cause impairment in drug metabolism and detoxification

Am J Clin Nutr 4(6):619624 Mota de S P, Richard AJ, Hang H, Stephens JM (2017) Transcriptional regulation of adipogenesis