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Front Pharmacol 10:968 Zong WX, Thompson CB (2006) Necrotic death as a cell fate

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In summary, this review paper encapsulates the nutritional role of Zn in the human immune system, with the hope of providing specific insights into Zn research

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Taken together, the mouse and human data suggest that circulating levels of formate driven by loss of ALDH1L2 correlate with increased tumour burden

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5) as a response to increased intracellular Zn to counteract the damaging effects of increased free radicals, causing these MTs to also bind Cu from food, since MTs have a higher affinity for Cu than for Zn [337,338,339]

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However, the cellular stress of the upstream events, i.e., reactive metabolite formation, GSH depletion, and protein adducts formation, is still present and this stress may trigger apoptosis in a limited number of cells (Figure 1)

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