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Front Pharmacol 10:968 Zong WX, Thompson CB (2006) Necrotic death as a cell fate

In summary, this review paper encapsulates the nutritional role of Zn in the human immune system, with the hope of providing specific insights into Zn research

Taken together, the mouse and human data suggest that circulating levels of formate driven by loss of ALDH1L2 correlate with increased tumour burden

5) as a response to increased intracellular Zn to counteract the damaging effects of increased free radicals, causing these MTs to also bind Cu from food, since MTs have a higher affinity for Cu than for Zn [337,338,339]

However, the cellular stress of the upstream events, i.e., reactive metabolite formation, GSH depletion, and protein adducts formation, is still present and this stress may trigger apoptosis in a limited number of cells (Figure 1)
