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It also contains a functional NF1 site that acts as a repressor (Yang et al., 2002)

In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms
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Drug Metab Dispos 29:855862 Serbinova E, Khwaja S, Reznick AZ, Packer L (1992) Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart

If youre dealing with a vitamin B12 deficiency, getting your levels back to normal requires a structured approach
