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This study is the first report on a strong therapeutic potential of ALA to rescue ototoxic hearing loss caused by cisplatin, and our data provide key evidence that ALA may act as a reducing agent for glutathione disulfide to increase glutathione levels on behalf of glutathione reductase

Notably, sex-specific differences have been observed, with female mice showing greater susceptibility to Nrf2 deficiency, potentially due to interactions with estrogen signaling