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Similarly, abnormal accumulation and aggregation of mitochondria in the inter-myofibrillar space was detected in iPSCs derived from an ALS patient bearing a VCP mutation (Bartolome et al., 2017)

Nauen, R., Reckmann, U., Thomzik, J., & Thielert, W

Defective metal use by mutant proteins due to oxidative stress is another cause of neurodegeneration 36

doi: 10.1159/000052822
Future research endeavors may benefit from unraveling the collective dynamics among different RCD modalities