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Description
Some drugs are so extensively metabolized on the first pass that they are not effective when given orally and must be administered by an alternative route that bypasses the liver (e.g., sublingual nitroglycerin, IV lidocaine)
Approximately 20% is absorbed through the stomach and 80% is absorbed through the small intestine
Restarting after a break
Thioredoxin (Trx) and glutaredoxin (Grx) proteins depend upon thiol peroxidase for their oxidizing potential and receive electrons from NADPH/GSH with the help of thiol reductases (Meyer and Hell, 2005)
Holm S, Baranto A, Kaigle Holm A, et al
