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Experimental basis for a role for sulfhydryls and dopamine in ulcerogenesis: A primer for cytoprotection--organoprotection

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The mechanism is well-characterized and scientifically sound NNMT overexpression in obese adipose tissue is well-documented, and its inhibition does restore metabolic function in cell culture and animal models

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Exercise is an important part of whole person care with multiple other benefits, and exercise should be prescribed along with the much-needed pharmaceuticals, such as GLP1a's or metformin, for multiple reasons such as reducing side effects such as sarcopaenia