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doi: 10.3390/cancers13184570 164 ChengJWangXQiuLLiYMarraikiNElgorbanAMet al

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According to Diagnostic and Statistical Manual of Mental Disorders V (DSM-V) [3] and International Statistical Classification of Diseases and Related Health Problems 11th (ICD-11) [4], BD can be classified into two main categories considering clinical features: BD type 1, when patients experience at least one manic episode and depressive episodes regularly, and BD type 2 when they undergo at least one depressive episode and at least one hypomanic episode and have no history of manic episodes [5]

This may be due to the fact that Mn 2+ ions are smaller and more tightly bound to polyP, making it easier to be wrapped in the cluster, while RER peptides are larger and have weaker interactions with polyP and can be dispersedly distributed in the area closer to the surface of the cluster (see details in Supplementary Figs

Analysis of variance and post-hoc test were performed to get significant differences among treatment means