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Funding This work was partially supported by JSPS KAKENHI Grant Numbers 25K09057 and 18K05584 to TH and EO-T, respectively

The increase in visceral fat may explain the changes in cholesterol fractions, which positively correlate with BMI, lipid peroxidation, and oxidized low-density lipoprotein (LDL) [50]

Moreover, Lip-1 reduced microglial activation and the secretion of pro-inflammatory cytokines such as IL-6 and TNF-, while mitigating oxidative stress, lipid peroxidation, mitochondrial damage and neuronal injury following LPS exposure

223,224 NADs can be precisely modified to improve their efficacy and stability while decreasing toxicity and immunogenicity

Thus, stimulation testing in patients with TS is unnecessary.59 rhGH therapy has been approved in the US for use in children with TS since 1996