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Oncostatin M receptor beta deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages

It does so by activating genes that are associated with repair and regeneration while suppressing those linked to inflammation and aging

Nature Medicine

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Although BSO+L-PAM were not as active in the TX-MM-030h cell line (established at relapse after therapy with myeloablative L-PAM) as in other cell lines, BSO+L-PAM had a greater than additive effect and induced 3 logs of cell kill