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JAMA 288 , 22822292 (2002)

Interestingly, tacrine is a relatively weak AChE inhibitor, as compared to donepezil or rivastigmine, with a complex mechanism of action involving other cholinergic structures, ion channels and monoaminergic systems [123]

The Nrf2 activation along with the thiamine formation may explain why high doses of the thiamine disulfides, expected to decrease cellular redox potential, do not have any negative action even upon the long-term administration (155)

Indeed, ample evidence has shown significant reduction of PUFAs, in particular AA and DHA in peripheral blood (plasma and erythrocyte membranes) of schizophrenia patients at different development stages (including ultra-high risk individuals, un-medicated first-episode and chronic patients [21,22,23,24,25,26,27,28,29,30,31,32,33]

The same solvents and gradients used for phenazine separation were employed but with a run time of 15 min