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On the one hand, the vast majority of studies on mitochondrial targeting are still in the preclinical stage, mainly focusing on in vitro cell experiments and in vivo animal model validation
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Implications for dosing frequency 9
It is not a replacement for treatment
Inhibition of LDHB upregulates STAT1, suppresses SLC7A11 expression and disrupts GSH metabolism, thereby surmounting intrinsic ferroptosis resistance in this subtype (131)
