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Ferroptotic cells activate macrophage functions and recruitment through damage-associated molecular patterns (DAMPs), which are endogenous danger signals that recruit and activate macrophages, thereby initiating immune defense mechanisms

10,11 Therefore, it is imperative that pharmacists recognize signs and symptoms of overdose and toxicity, and counsel their patients on proper dosing and usage

Mesna is widely used as a systemic protective agent against chemotherapy toxicity

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