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Moravek MB, Yin P, Ono M, et al

Besides, modulating the CCL2-CCR2 axis with CCR2 inhibitors or PC3-secreted microprotein (PSMP)-neutralizing antibodies, or blocking S100A8/A9-mediated intercellular interactions, to diminish the recruitment and accumulation of pro-inflammatory monocyte-derived macrophages constitutes a pivotal therapeutic approach for alleviating post-AKI inflammation and preventing its advancement to fibrosis [316]

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by adjusting pressure, temperature, and the use of co-solvents such as ethanol or water, it can be optimized for higher purity and targeted extraction of diverse phenolic compounds (59)