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Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) is the master coactivator of mitochondrial biogenesis, serving as an effector molecule in a variety of signaling pathways, such as the mTOR [55], AMPK [56] and MAPK signaling pathways [57], and inhibiting pathways such as the PD-1 signaling pathway

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Dry, flaky skin: Hydration is key for smoother, softer skin