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10.1083/jcb.200612116

The relative amounts of each form determine the cellular redox status (GSH/GSSG ratio) which is often used as a marker of antioxidative capacity of cells [2]

The excellent clinical manifestations of Tan IIA provide supportive evidence for targeting the GSH system in the treatment of heart diseases, which may be promising for transforming natural compounds from basic research to clinical applications

Cell Metab (2011) 13(4):45060

Thus, the inhibition of cystine import by SLC7A11 limits GSH synthesis, which indirectly reduces GPX4 activity
