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Moreover, tryptophan biosynthesis is frequently linked to the production of indole-derived secondary metabolites, such as indole-3-acetic acid (IAA), which function as signaling molecules or defense agents in microbial interactions, particularly in response to antimicrobials (Li 2023)

Continuous efforts have been made to advance the clinical translation of MHT

doi: 10.1016/j.pharmthera.2007.04.001

In support of a role of NRF2 in OSA, it has also been found that restoration of NRF2 activity can mitigate cognitive impairment and inflammation in a model of IH and sleep fragmentation by modulating ER stress and regulating the expression of the antioxidant gene Prdx1 (Qiu et al

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